Phenotypic robustness determines genetic regulation of complex traits

A balance between phenotypic variability and robustness is crucial for populations to adapt to multiple selection pressures. The plasticity of genetic pathways underlies this balance. We investigated this plasticity by studying the regulation of phenotypic mean and variance in a

Phenotypic robustness determines genetic regulation of complex traits

A balance between phenotypic variability and robustness is crucial for populations to adapt to multiple selection pressures. The plasticity of genetic pathways underlies this balance. We investigated this plasticity by studying the regulation of phenotypic mean and variance in a

Unraveling the genetic architecture of cryptic genetic variation

Cryptic genetic variation (CGV), hidden under most conditions, is the repressed genetic potential that can facilitate adaptation and evolution. The conditional manifestation of CGV has been claimed to explain the background dependence of causal loci as well as missing heritability.

Unraveling the genetic architecture of cryptic genetic variation

Cryptic genetic variation (CGV), hidden under most conditions, is the repressed genetic potential that can facilitate adaptation and evolution. The conditional manifestation of CGV has been claimed to explain the background dependence of causal loci as well as missing heritability.

Differential Regulation of Cryptic Genetic Variation Shapes the Genetic Interactome Underlying Complex Traits

Cryptic genetic variation (CGV) refers to genetic variants whose effects are buffered in most conditions but manifest phenotypically upon specific genetic and environmental perturbations. Despite having a central role in adaptation, contribution of CGV to regulation of quantitative traits is

Differential Regulation of Cryptic Genetic Variation Shapes the Genetic Interactome Underlying Complex Traits

Cryptic genetic variation (CGV) refers to genetic variants whose effects are buffered in most conditions but manifest phenotypically upon specific genetic and environmental perturbations. Despite having a central role in adaptation, contribution of CGV to regulation of quantitative traits is

Genetic Regulation of Phenotypic Plasticity and Canalisation in Yeast Growth

The ability of a genotype to show diverse phenotypes in different environments is called phenotypic plasticity. Phenotypic plasticity helps populations to evade extinctions in novel environments, facilitates adaptation and fuels evolution. However, most studies focus on understanding the genetic basis

Genetic Regulation of Phenotypic Plasticity and Canalisation in Yeast Growth

The ability of a genotype to show diverse phenotypes in different environments is called phenotypic plasticity. Phenotypic plasticity helps populations to evade extinctions in novel environments, facilitates adaptation and fuels evolution. However, most studies focus on understanding the genetic basis

Document Categorization Using Semantic Relatedness and Anaphora Resolution : A Discussion

Document categorization is the process of assigning pre-defined categories to textual documents. State-of-the art approaches have modelled documents in terms of corpus-length long vectors and viewed the problem only from a syntactic perspective. We develop a general measure to estimate

Document Categorization Using Semantic Relatedness and Anaphora Resolution : A Discussion

Document categorization is the process of assigning pre-defined categories to textual documents. State-of-the art approaches have modelled documents in terms of corpus-length long vectors and viewed the problem only from a syntactic perspective. We develop a general measure to estimate

Sequence-based prediction of protein–protein interaction sites with L1-logreg classifier

Protein–protein interactions are of central importance for virtually every process in a living cell. Information about the interaction sites in proteins improves our understanding of disease mechanisms and can provide the basis for new therapeutic approaches. Since a multitude of

Sequence-based prediction of protein–protein interaction sites with L1-logreg classifier

Protein–protein interactions are of central importance for virtually every process in a living cell. Information about the interaction sites in proteins improves our understanding of disease mechanisms and can provide the basis for new therapeutic approaches. Since a multitude of

SPRINGS: Prediction of Protein-Protein Interaction Sites Using Artificial Neural Networks

Knowledge of protein-protein interaction sites provides an important base for deciphering novel drug targets. But on account of biological complexity and transient forms, determination of these sites is a challenge in biology. Various computational approaches are being explored for relevant

SPRINGS: Prediction of Protein-Protein Interaction Sites Using Artificial Neural Networks

Knowledge of protein-protein interaction sites provides an important base for deciphering novel drug targets. But on account of biological complexity and transient forms, determination of these sites is a challenge in biology. Various computational approaches are being explored for relevant

Games in Queues : Operations Research (Game Theory)

This is the abstract of my thesis. My first step in Operations Research. Traditional Queueing and Transportation Theory has for long supplied fundamental tools for understanding queueing behaviour arising in various real-life scenarios. Particularly important to consider are customers’ strategic

Games in Queues : Operations Research (Game Theory)

This is the abstract of my thesis. My first step in Operations Research. Traditional Queueing and Transportation Theory has for long supplied fundamental tools for understanding queueing behaviour arising in various real-life scenarios. Particularly important to consider are customers’ strategic

The BITS “Bhadang” Revolution !

India’s rich and middle class on an average have 2.5 meals per day. While the ones whose homes’ roofs merely exist alleviate the crying crows in their solar plexuses by eating twice a day. So given India’s population below the

The BITS “Bhadang” Revolution !

India’s rich and middle class on an average have 2.5 meals per day. While the ones whose homes’ roofs merely exist alleviate the crying crows in their solar plexuses by eating twice a day. So given India’s population below the

Anti-Bedbugs Riots: The Exaggerated Letter!

TOPIC: REQUEST FOR IMPLEMENTING PEST-CONTROL IN CH3 Sir I, Kaustubh Dhole (CH3-202) on behalf of CH3, would like to bring to light the bedbug-epidemic which has taken a heavy toll on CH3. Since the end of the last semester, an

Anti-Bedbugs Riots: The Exaggerated Letter!

TOPIC: REQUEST FOR IMPLEMENTING PEST-CONTROL IN CH3 Sir I, Kaustubh Dhole (CH3-202) on behalf of CH3, would like to bring to light the bedbug-epidemic which has taken a heavy toll on CH3. Since the end of the last semester, an

The Final Goodbye Gene!!!

I still can’t forget the memories of those 12 months spent in transcribing, translating and then replicating myself in a subject which I detested initially!!! Yes Aai, I am finally bringing home the bacon. The bacon of Biological Sciences! Right

The Final Goodbye Gene!!!

I still can’t forget the memories of those 12 months spent in transcribing, translating and then replicating myself in a subject which I detested initially!!! Yes Aai, I am finally bringing home the bacon. The bacon of Biological Sciences! Right

/ Goa

Goa’s Restaurants: Going the Vasco Way

Goa is boring! Goans are lazy! There is no fun in Goa except for the beaches! Coconut food is not my cup of tea. Only Christmas defines Goa…..Stop! Stop! Thambaa!….These grapevine lines do not even hint about Goa. Rather, they

/ Goa

Goa’s Restaurants: Going the Vasco Way

Goa is boring! Goans are lazy! There is no fun in Goa except for the beaches! Coconut food is not my cup of tea. Only Christmas defines Goa…..Stop! Stop! Thambaa!….These grapevine lines do not even hint about Goa. Rather, they

BITS Namah Shivay!

The anticipation for the most awaited and the lengthiest vacation of all, the colossal summer is over and time has turned the calendar’s new page as the end of July nears. As the usual summers are being spent in Mumbai,

BITS Namah Shivay!

The anticipation for the most awaited and the lengthiest vacation of all, the colossal summer is over and time has turned the calendar’s new page as the end of July nears. As the usual summers are being spent in Mumbai,

“Don’t tickle the Dragon”….CH3

Zephyr boyyyyy! Zephyr! Time to get frenzied! Zephyr 2011, La guerre of hostels has begun! Whether you pronounce it as Za-fire or Ze-fur, nothing matters more than this winter calefaction as the zeal and hullabaloo this year is definitely going

“Don’t tickle the Dragon”….CH3

Zephyr boyyyyy! Zephyr! Time to get frenzied! Zephyr 2011, La guerre of hostels has begun! Whether you pronounce it as Za-fire or Ze-fur, nothing matters more than this winter calefaction as the zeal and hullabaloo this year is definitely going

PepsiBurma(kaustubhdhole.wordpress.com)

Pepsi, the only solution to save the Burmese Rupee

If you ask me whether PepsiCo has a moral obligation to pull its products and brand name out of Burma, then I would simply say PepsiCo doesn’t. At least not to withdraw completely from Burma. Why? Due to harsh military

PepsiBurma(kaustubhdhole.wordpress.com)

Pepsi, the only solution to save the Burmese Rupee

If you ask me whether PepsiCo has a moral obligation to pull its products and brand name out of Burma, then I would simply say PepsiCo doesn’t. At least not to withdraw completely from Burma. Why? Due to harsh military

Is it time to say “Mumbai to Karachi”?

Have you watched the 1972 mega blockbuster ‘Bombay to Goa’ or any film like that whose journey dawns from Bombay? Never mind if you haven’t. You’ve lost nothing because it’s no more the same destination. The new destination is somewhere in

Is it time to say “Mumbai to Karachi”?

Have you watched the 1972 mega blockbuster ‘Bombay to Goa’ or any film like that whose journey dawns from Bombay? Never mind if you haven’t. You’ve lost nothing because it’s no more the same destination. The new destination is somewhere in

Operating Systems are advancing to a new level while booting on the cloud in this era of Technology++

No more can you say that the new decade is an age of technology. Technology has grown so rapidly that it’s time we rename it to something like Technology++ or Technology#. A lot new unimaginable is to be witnessed in

Operating Systems are advancing to a new level while booting on the cloud in this era of Technology++

No more can you say that the new decade is an age of technology. Technology has grown so rapidly that it’s time we rename it to something like Technology++ or Technology#. A lot new unimaginable is to be witnessed in

The Hindi Revolution and the 21st century…

Just about a few days ago, when I was glancing through the number of languages being spoken around the globe and their strength, I was astonished, rather amazed at the figures which revealed that Hindi (or Hindi/Urdu or Hindustani at

The Hindi Revolution and the 21st century…

Just about a few days ago, when I was glancing through the number of languages being spoken around the globe and their strength, I was astonished, rather amazed at the figures which revealed that Hindi (or Hindi/Urdu or Hindustani at

Protected: Political parties pick up Ramdev’s fast to blame each other, Soul purpose of fast forgotten…

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Protected: Political parties pick up Ramdev’s fast to blame each other, Soul purpose of fast forgotten…

There is no excerpt because this is a protected post.

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World Cup 2011 with Dhoni’s men at their best!

Yes! A moment of mammoth success was visible on millions of Indians on the 2nd of April, 2011 as the proud captain Mahendra Singh Dhoni’s men lifted the World Cup trophy exactly 26 years after 1983’s superb final. (And obviously,

World Cup 2011 with Dhoni’s men at their best!

Yes! A moment of mammoth success was visible on millions of Indians on the 2nd of April, 2011 as the proud captain Mahendra Singh Dhoni’s men lifted the World Cup trophy exactly 26 years after 1983’s superb final. (And obviously,